Clinical investigations on anesthesia-induced developmental

Best Pract Res Clin Anaesthesiol · Mar 2023

Review

Clinical investigations on anesthesia-induced developmental neurotoxicity: The knowns, the unknowns and future prospects.

Pre-clinical experimental evidence, along with a plausible biological rational suggests that exposure of neonates and young children to anesthesia may harm brain development. However, the translational relevance of these observations remains unsolved. While a variety of lasting morpho-functional effects can be attributed to early life exposure to anesthetics in laboratory animals, we do not have a convincing human phenotype that reflects any causal effects of general anesthetic exposure on brain development and functional outcome. This review is aimed to provide a comprehensive description of the current state of clinical research alongside exploring future challenges in this field by focusing on the critical appraisal of methodological approaches applied in clinical research into developmental anesthesia neurotoxicity.

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- Laszlo Vutskits and Andrew Davidson.
- Department of Anesthesiology, Pharmacology, Intensive Care, and Emergency Medicine, University Hospitals of Geneva, Geneva, Switzerland; Geneva Neuroscience Center, University of Geneva, Geneva, Switzerland. Electronic address: Laszlo.Vutskits@hcuge.ch.
- Best Pract Res Clin Anaesthesiol. 2023 Mar 1; 37 (1): 405140-51.
AbstractPre-clinical experimental evidence, along with a plausible biological rational suggests that exposure of neonates and young children to anesthesia may harm brain development. However, the translational relevance of these observations remains unsolved. While a variety of lasting morpho-functional effects can be attributed to early life exposure to anesthetics in laboratory animals, we do not have a convincing human phenotype that reflects any causal effects of general anesthetic exposure on brain development and functional outcome. This review is aimed to provide a comprehensive description of the current state of clinical research alongside exploring future challenges in this field by focusing on the critical appraisal of methodological approaches applied in clinical research into developmental anesthesia neurotoxicity.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.

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Clinical investigations on anesthesia-induced developmental neurotoxicity: The knowns, the unknowns and future prospects.

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