• Keita Shibahashi, Hiroyuki Ohbe, Hiroki Matsui, and Hideo Yasunaga.
• 1Department of Clinical Epidemiology and Health Economics, School of Public Health, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo; and.
• J. Neurosurg. 2023 Dec 1; 139 (6): 151415221514-1522.

ObjectiveIntracranial pressure (ICP) monitoring is recommended for the management of severe traumatic brain injury (TBI). The clinical benefit of ICP monitoring remains controversial, however, with randomized controlled trials showing negative results. Therefore, this study investigated the real-world impact of ICP monitoring in managing severe TBI.MethodsThis observational study used the Japanese Diagnosis Procedure Combination inpatient database, a nationwide inpatient database, from July 1, 2010, to March 31, 2020. The study included patients aged 18 years or older who were admitted to an intensive care or high-dependency unit with a diagnosis of severe TBI. Patients who did not survive or were discharged on admission day were excluded. Between-hospital differences in ICP monitoring were quantified using the median odds ratio (MOR). A one-to-one propensity score matching (PSM) analysis was conducted to compare patients who initiated ICP monitoring on the admission day with those who did not. Outcomes in the matched cohort were compared using mixed-effects linear regression analysis. Linear regression analysis was used to estimate interactions between ICP monitoring and the subgroups.ResultsThe analysis included 31,660 eligible patients from 765 hospitals. There was considerable variability in the use of ICP monitoring across hospitals (MOR 6.3, 95% confidence interval [CI] 5.7-7.1), with ICP monitoring used in 2165 patients (6.8%). PSM resulted in 1907 matched pairs with highly balanced covariates. ICP monitoring was associated with significantly lower in-hospital mortality (31.9% vs 39.1%, within-hospital difference -7.2%, 95% CI -10.3% to -4.2%) and longer length of hospital stay (median 35 vs 28 days, within-hospital difference 6.5 days, 95% CI 2.6-10.3). There was no significant difference in the proportion of patients with unfavorable outcomes (Barthel index < 60 or death) at discharge (80.3% vs 77.8%, within-hospital difference 2.1%, 95% CI -0.6% to 5.0%). Subgroup analyses demonstrated a quantitative interaction between ICP monitoring and the Japan Coma Scale (JCS) score for in-hospital mortality, with a greater risk reduction with higher JCS score (p = 0.033).ConclusionsICP monitoring was associated with lower in-hospital mortality in the real-world management of severe TBI. The results suggest that active ICP monitoring is associated with improved outcomes after TBI, while the indication for monitoring might be limited to the most severely ill patients.

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