Pharmacokinetic and pharmacodynamic drug display and

Curr Opin Anaesthesiol · Aug 2023

Review

Pharmacokinetic and pharmacodynamic drug display and simulation systems in anesthesia practice.

This review explores the use of tools and displays based on pharmacokinetic and pharmacodynamic (PK/PD) modelling of drugs used in anesthesia. The primary focus is on those tools designed to illustrate the interactions between two or more drugs, or classes of drugs, and in particular, their use in a real-time clinical support role. Off-line, educational tools are also explored. ⋯ PK/PD simulation is a useful tool for exposition of the relationship between drug dosing and effect. The initial promise of real-time tools has yet to be realized in routine clinical practice.

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- R Ross Kennedy.
- University of Otago: Christchurch, Christchurch, Aotearoa.
- Curr Opin Anaesthesiol. 2023 Aug 1; 36 (4): 407413407-413.
Purpose Of ReviewThis review explores the use of tools and displays based on pharmacokinetic and pharmacodynamic (PK/PD) modelling of drugs used in anesthesia. The primary focus is on those tools designed to illustrate the interactions between two or more drugs, or classes of drugs, and in particular, their use in a real-time clinical support role. Off-line, educational tools are also explored.Recent FindingsDespite initial promise and encouraging supporting data, the use of real-time display of PK/PD is not common except in target-controlled infusion (TCI) pumps.SummaryPK/PD simulation is a useful tool for exposition of the relationship between drug dosing and effect. The initial promise of real-time tools has yet to be realized in routine clinical practice.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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Pharmacokinetic and pharmacodynamic drug display and simulation systems in anesthesia practice.

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