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Editorial Comment
Amyloid beta and postoperative delirium: partners in crime or strangers in the dark?
- Tyler H Reekes, Michael J Devinney, and Miles Berger.
- Department of Anesthesiology, Duke University Medical Center, Durham, NC, USA.
- Br J Anaesth. 2023 Aug 1; 131 (2): 205208205-208.
AbstractPostoperative delirium is a particularly debilitating complication of surgery and perioperative care. Although the aetiology of postoperative delirium is not entirely understood, recent evidence suggests that Alzheimer's disease and related dementias pathology plays an important role in the development of postoperative delirium. A recent study evaluating postoperative changes in plasma beta amyloid (Aβ) levels found increased Aβ across the postoperative period, but the association with postoperative delirium incidence and severity was variable. These findings support the idea that Alzheimer's disease and related dementias pathology in combination with blood-brain barrier dysfunction and neuroinflammation may impart risk for postoperative delirium.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.
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