• Internal medicine · Feb 2024

    Clinicopathologic Features of Adult-onset Still's Disease Complicated by Severe Liver Injury.

    • Miho Kurokawa, Tomonobu Hioki, Tomomi Aoyagi, Motoi Takahashi, Koji Imoto, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, and Yoshihiro Ogawa.
    • Department of Medicine and Bioregulatory Science, Graduate School of Medical Sciences, Kyushu University, Japan.
    • Intern. Med. 2024 Feb 15; 63 (4): 503511503-511.

    AbstractAdult-onset Still's disease (AOSD) is a systemic inflammatory disorder. Severe liver injury has rarely been reported, although liver enzyme elevation is a common complication of AOSD. We herein report four cases of relapsed AOSD with severe liver disorder by tapering or terminating corticosteroids. Liver specimens revealed robust infiltration of inflammatory cells throughout the lobule, especially cluster of differentiation (CD) 8-positive cells. Relapsed AOSD was refractory to corticosteroid reintroduction and required immunosuppressants. Severe liver injury with AOSD is pathologically characterized by extensive lobular infiltration of CD8-positive cells, and we should consider additive immunosuppressive agents on corticosteroids for treatment.

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