• Internal medicine · Feb 2024

    Case Reports

    Efficacy of Bisphosphonate for Urolithiasis Complicated by Osteogenesis Imperfecta: A Case Report.

    • Ryusuke Deguchi, Yasuo Kohjimoto, Yohei Maruyama, Yuya Iwahashi, Satoshi Muraoka, Takahito Wakamiya, Shimpei Yamashita, and Isao Hara.
    • Department of Urology, Wakayama Medical University, Japan.
    • Intern. Med. 2024 Feb 1; 63 (3): 439442439-442.

    AbstractA 44-year-old man with osteogenesis imperfecta presented with left renal colic. Non-contrast computed tomography revealed a stone (10×9 mm) in the left upper ureter. Ureteroscopic lithotripsy was performed twice and stone-free status was achieved. An analysis of the stone revealed a mixed composition including calcium oxalate and calcium phosphate. Postoperatively, we administered bisphosphonates to prevent recurrence of urolithiasis, as 24-hour urine collection revealed marked hypercalciuria. Eighteen months after surgery, the urinary calcium levels had normalized, and there was no recurrence of urolithiasis. Osteogenesis imperfecta can be complicated by urolithiasis, but bisphosphonates may be useful in preventing recurrence of this disease.

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