• Internal medicine · Feb 2024

    Case Reports

    A Case of Autoimmune Polyglandular Syndrome Type 3 Complicated with IgG4-related Disease.

    • Yusuke Murata, Masaki Haneda, Nobukazu Miyakawa, Saiko Nishida, Nobuhiro Kajihara, Sarie Maeda, Kaoru Ono, Satoko Hanatani, Motoyuki Igata, Yuki Takaki, Hiroyuki Motoshima, Hideki Kishikawa, and Eiichi Araki.
    • Department of Diabetes, Metabolism and Endocrinology, Kumamoto University Hospital, Japan.
    • Intern. Med. 2024 Feb 1; 63 (3): 425431425-431.

    AbstractA 52-year-old Japanese woman developed type 1 diabetes mellitus (type 1 DM) at 41 years old. She became complicated with Hashimoto's disease and showed swelling of both submandibular glands, which was diagnosed as IgG4-related disease (IgG4-RD). This is a rare case of a Japanese patient with autoimmune polyglandular syndrome type 3A (APS-3A) coexisting with autoimmune thyroid disease (AITD) and type 1 DM complicated by IgG4-RD. Bilateral submandibular gland resection was successfully performed without steroid therapy. We discuss the possibility that the immunological pathogenic mechanisms of APS-3A and IgG4-RD are related.

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