• Thomas Fuchs-Buder, Sorin J Brull, FagerlundMalin JonssonMJPerioperative Medicine and Intensive Care, Karolinska University Hospital, Stockholm, Sweden., J Ross Renew, Guy Cammu, Glenn S Murphy, Michiel Warlé, Matias Vested, Béla Fülesdi, Reka Nemes, Malachy O Columb, Daniela Damian, Peter J Davis, Hajime Iwasaki, and Lars I Eriksson.
• Department of Anaesthesia, Critical Care & Perioperative Medicine, University Hospital Nancy, Nancy, France.
• Acta Anaesthesiol Scand. 2023 Sep 1; 67 (8): 9941017994-1017.

AbstractThe set of guidelines for good clinical research practice in pharmacodynamic studies of neuromuscular blocking agents was developed following an international consensus conference in Copenhagen in 1996 (Viby-Mogensen et al., Acta Anaesthesiol Scand 1996, 40, 59-74); the guidelines were later revised and updated following the second consensus conference in Stockholm in 2005 (Fuchs-Buder et al., Acta Anaesthesiol Scand 2007, 51, 789-808). In view of new devices and further development of monitoring technologies that emerged since then, (e.g., electromyography, three-dimensional acceleromyography, kinemyography) as well as novel compounds (e.g., sugammadex) a review and update of these recommendations became necessary. The intent of these revised guidelines is to continue to help clinical researchers to conduct high-quality work and advance the field by enhancing the standards, consistency, and comparability of clinical studies. There is growing awareness of the importance of consensus-based reporting standards in clinical trials and observational studies. Such global initiatives are necessary in order to minimize heterogeneous and inadequate data reporting and to improve clarity and comparability between different studies and study cohorts. Variations in definitions of endpoints or outcome variables can introduce confusion and difficulties in interpretation of data, but more importantly, it may preclude building of an adequate body of evidence to achieve reliable conclusions and recommendations. Clinical research in neuromuscular pharmacology and physiology is no exception.© 2023 The Authors. Acta Anaesthesiologica Scandinavica published by John Wiley & Sons Ltd on behalf of Acta Anaesthesiologica Scandinavica Foundation.

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