• Yutao He, Ziyi Tang, Na Tang, Yu Lu, Fangfang Niu, Jiao Ye, Zheng Zhang, Chenghong Fang, and Lei Yao.
• Department of Laboratory Medicine, Guiqian International General Hospital, Guiyang, Guizhou Province, China.
• Medicine (Baltimore). 2023 Jun 23; 102 (25): e34137e34137.

RationaleEctopic ACTH-producing pituitary adenoma (EAPA) of the clivus region is extraordinarily infrequent condition and merely a few reports have been reported to date.Patient ConcernsThe patient was a 53-year-old woman who presented with Cushing-like appearances and a soft tissue mass in the clivus region.DiagnosesThe final diagnosis of clivus region EAPA was established by clinical, radiological and histopathological findings.InterventionsThe patient underwent gross total clivus tumor resection via transsphenoidal endoscopy.OutcomesHalf a year after surgery, the patient Cushing-like clinical manifestations improved significantly, and urinary free cortisol and serum adrenocorticotropin (ACTH) returned to normal.LessonsGiven the extreme scarcity of these tumors and their unique clinical presentations, it may be possible to misdiagnose and delayed treatment. Accordingly, it is especially crucial to summarize such lesions through our present case and review the literature for their precise diagnosis and the selection of optimal treatment strategies.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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