• Hsu-Ju Kao, Tsair-Wei Chien, Wen-Chung Wang, Willy Chou, and Julie Chi Chow.
• Department of Internal Medicine, Chi Mei Medical Center, Chiali, Taiwan.
• Medicine (Baltimore). 2023 Jun 23; 102 (25): e34068e34068.

BackgroundThe application of large language models in clinical decision support (CDS) is an area that warrants further investigation. ChatGPT, a prominent large language models developed by OpenAI, has shown promising performance across various domains. However, there is limited research evaluating its use specifically in pediatric clinical decision-making. This study aimed to assess ChatGPT's potential as a CDS tool in pediatrics by evCDSaluating its performance on 8 common clinical symptom prompts. Study objectives were to answer the 2 research questions: the ChatGPT's overall grade in a range from A (high) to E (low) compared to a normal sample and the difference in assessment of ChatGPT between 2 pediatricians.MethodsWe compared ChatGPT's responses to 8 items related to clinical symptoms commonly encountered by pediatricians. Two pediatricians independently assessed the answers provided by ChatGPT in an open-ended format. The scoring system ranged from 0 to 100, which was then transformed into 5 ordinal categories. We simulated 300 virtual students with a normal distribution to provide scores on items based on Rasch rating scale model and their difficulties in a range between -2 to 2.5 logits. Two visual presentations (Wright map and KIDMAP) were generated to answer the 2 research questions outlined in the objectives of the study.ResultsThe 2 pediatricians' assessments indicated that ChatGPT's overall performance corresponded to a grade of C in a range from A to E, with average scores of -0.89 logits and 0.90 logits (=log odds), respectively. The assessments revealed a significant difference in performance between the 2 pediatricians (P < .05), with scores of -0.89 (SE = 0.37) and 0.90 (SE = 0.41) in log odds units (logits in Rasch analysis).ConclusionThis study demonstrates the feasibility of utilizing ChatGPT as a CDS tool for patients presenting with common pediatric symptoms. The findings suggest that ChatGPT has the potential to enhance clinical workflow and aid in responsible clinical decision-making. Further exploration and refinement of ChatGPT's capabilities in pediatric care can potentially contribute to improved healthcare outcomes and patient management.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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