• J Palliat Med · Nov 2023

    Case Reports

    Effects and Limitations of Naldemedine for Opioid-Induced Urinary Retention: A Case Report.

    • Naoki Suzuki, Megumi Okuyama, and Kohei Kamiya.
    • Department of Palliative Medicine, Yamagata Prefectural Central Hospital, Yamagata, Japan.
    • J Palliat Med. 2023 Nov 1; 26 (11): 159315951593-1595.

    AbstractA 78-year-old man with postoperative recurrence of esophageal cancer was admitted to the hospital due to chest pain and dyspnea. Oral short-acting opioids provided some relief, but chest pain persisted and worsened, leading to the initiation of a transdermal fentanyl patch. However, the patient developed opioid-induced urinary retention, which was treated with a naldemedine, a medication used for opioid-induced constipation and urinary retention. Opioid switching led to recurrent urinary retention, requiring placement of a urinary catheter. The patient ultimately required continuous deep sedation for refractory symptoms and died several days later.

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