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- Hayato Fujioka, Kota Kakeshita, Teruhiko Imamura, Yu Arisawa, Shingo Yokoyama, Hidenori Yamazaki, Tsutomu Koike, Takashi Minamisaka, Kenichi Hirabayashi, and Koichiro Kinugawa.
- The Second Department of Internal Medicine, University of Toyama, Japan.
- Intern. Med. 2024 Feb 15; 63 (4): 533539533-539.
AbstractPembrolizumab, an immune checkpoint inhibitor, is used to treat a variety of refractory malignancies. However, these agents are sometimes associated with immune-related adverse events. A 71-year-old woman received pembrolizumab-integrated chemotherapy to treat her recurrent mandibular gingival cancer. Five months after stopping pembrolizumab, she developed acute tubulointerstitial nephritis associated with Fanconi syndrome and type 1 renal tubular acidosis, which resolved with steroid therapy. We experienced a case of pembrolizumab-induced Fanconi syndrome and type 1 renal acidosis. We recommend follow-up of the tubular function in addition to the renal function even after discontinuation of pembrolizumab.
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