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Case Reports
Clinical Response of Primary Malignant Pericardial Mesothelioma with Peritoneal Dissemination to Nivolumab.
- Shun Fujiwara, Yoshihito Kano, Yasuhiro Maejima, Tomoyuki Fujioka, Kazuhiro Tamura, Susumu Kirimura, Satoshi Miyake, and Ryuichi Okamoto.
- Department of Gastroenterology and Hepatology, Tokyo Medical and Dental University (TMDU), Japan.
- Intern. Med. 2024 Feb 15; 63 (4): 513519513-519.
AbstractMalignant pericardial mesothelioma (MPM) is extremely rare, and peritoneal dissemination has not yet been reported. There is no consensus regarding appropriate pharmacological treatment for MPM, including immune checkpoint inhibitors (ICIs). We herein report a 36-year-old man with MPM diagnosed by peritoneal dissemination and treated with an ICI. Cytology of the ascites revealed malignant peritonitis, and a re-evaluation of a pericardial biopsy performed at the previous hospital led to a diagnosis of MPM. The patient was treated with nivolumab and showed a clinical response despite several complications, such as renal dysfunction and performance status deterioration. This case report provides suggestive information for the diagnosis and ICI therapy of a rare type of mesothelioma.
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