• Eva de Miguel-Balsa, Teresa Blasco-Ruso, Norma Gómez-Medrano, María Mirabet-Guijarro, Alba Martínez-Pérez, and Adoración Alcalá-López.
• Servicio de Medicina Intensiva, Hospital General Universitario de Elche, Elche, Alicante, España.
• Med Intensiva. 2023 Mar 13.

ObjectiveTo describe the characteristics of patients with acute respiratory distress syndrome due to bilateral COVID-19 pneumonia on invasive mechanical ventilation (IMV) and analyze the effect of prolonged prone decubitus > 24 h (PPD) compared to prone decubitus < 24 h (PD).DesignRetrospective observational descriptive study. Uni and bivariate analysis.SettingDepartment of Intensive Care Medicine. General University Hospital of Elche.ParticipantsPatients with SARS-CoV-2 pneumonia (2020-2021) in VMI for moderate-severe acute respiratory distress syndrome, ventilated in PD.InterventionsIMV. PD maneuvers.Main Variables Of InterestSociodemographic; analgo-sedation; neuromuscular blockade; PD (duration), ICU stay and mortality, days of IMV; non-infectious complications; health care-associated infections.ResultsFifty-one patients required PD and of these 31 (69.78%) required PPD. No differences were found in patient characteristics (sex, age, comorbidities, initial severity, antiviral and anti-inflammatory treatment received). Patients on PPD had lower tolerance to supine ventilation (61.29 vs. 89.47%, p = 0.031), longer hospital stay (41 vs. 30 days, p = 0.023), more days of IMV (32 vs. 20 days, p = 0.032), longer duration of neuromuscular blockade (10.5 vs. 3 days, p = 0.0002), as well as a higher percentage of episodes of orotracheal tube obstruction (48.39 vs. 15%, p = 0.014).ConclusionsPPD was associated with higher resource use and complications in patients with moderate-severe acute respiratory distress syndrome by COVID-19.© 2023 Elsevier España, S.L.U. y SEMICYUC. All rights reserved.

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