• Intern Emerg Med · Sep 2023

    Cell and cytokine analyses from bronchoalveolar lavage in non-critical COVID-19 pneumonia.

    • Camille Rolland-Debord, Laurence Piéroni, Farah Bejar, Audrey Milon, Pascaline Choinier, Emmanuelle Blin, Juliette Bravais, Pierre Halitim, Alice Letellier, Juliette Camuset, Antoine Parrot, Anne Fajac, and Jacques Cadranel.
    • Department of Pneumology and Thoracic Oncology, AP-HP Hôpital Tenon, Sorbonne Université, Paris, France. crollanddebord@chu-clermontferrand.fr.
    • Intern Emerg Med. 2023 Sep 1; 18 (6): 172317321723-1732.

    AbstractCell and cytokine analyses from bronchoalveolar lavage (BAL) in non-critically ill patients with COVID-19 pneumonia are poorly described. This study focused on patients hospitalized in the non-intensive care unit for either suspected COVID-19 pneumonia or persistent respiratory symptoms following proven COVID-19 pneumonia. Overall, 54 patients who underwent BAL between April 2020 and February 2021 for suspected or follow-up of proven COVID-19 pneumonia were included. Based on SARS-CoV-2 polymerase chain reaction test results and clinical follow-up, three pulmonary disease groups were defined: non-COVID-19 (n = 20), acute COVID-19 (n = 13), and post-COVID-19 (n = 24) pneumonia patients. Cytological and cytokine analyses were performed on BAL fluid (IL-1β, IL-6, IL-8, IL-10, TNF-α, IFN-γ, HGF, and TGF-β), with investigators blinded to the patient groups. Lymphocytic alveolitis with plasmocytes was observed in acute COVID-19 pneumonia, returning to normal post-COVID-19. The highest cytokine levels were observed in COVID-19 patients, with significantly increased IFN-γ, IL-10, and HGF levels compared to non-COVID-19 patients, while significantly decreased IL-6, IL-8, IL-10, IFN-γ, TNF-α, and HGF levels were noted in post-COVID-19 patients. In COVID-19 patients, correlations between IL-10, TNF-α and IFN-γ concentrations were found. Lymphocytic alveolitis with plasmacytosis was found in non-critical COVID-19 pneumonia This alveolitis is associated with the presence of IL-6, IL-8, IL-10, TNF-α, IFN-γ and HGF. Alveolitis and cytokines levels decreased in post-COVID-19 pneumonia.© 2023. The Author(s), under exclusive licence to Società Italiana di Medicina Interna (SIMI).

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