• Lv Tian, Zhiyuan Zhang, Yuting Mao, and Minru Zong.
• School of Nursing, Jilin University, Changchun, China.
• Medicine (Baltimore). 2023 Jun 30; 102 (26): e34131e34131.

BackgroundTo examine the association between pregnant women with rheumatoid arthritis (RA) and the risk of preeclampsia.MethodsThis study was registered on the International Prospective Register of Systematic Reviews (PROSPERO) under the number CRD42022361571. The primary outcome was preeclampsia. Two evaluators independently reviewed the included studies, assessed their risk of bias, and extracted the data. Unadjusted and adjusted ratios with 95% confidence intervals and 95% prediction intervals were calculated. Heterogeneity was quantified using the І2 statistic, where І2 ≥ 50% indicated the presence of significant heterogeneity. Subgroup and sensitivity analyses were performed to test the robustness of the overall findings.ResultsA total of 8 studies, including 10,951,184 pregnant women, of whom 13,333 were diagnosed with RA, met the inclusion criteria. Meta-analysis revealed that pregnant women with RA were significantly more likely to develop preeclampsia than those without RA (pooled odds ratio, 1.66; 95% confidence interval, 1.52-1.80; P < .001; І2 < .001).ConclusionRA during pregnancy is associated with higher odds of preeclampsia.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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