• Amber N Edinoff, Dorothy Askins, Elena Bobo, Kathryn L White, Zahaan Eswani, Eric D Jackson, Danielle M Wenger, Aaron J Kaye, Elyse M Cornett, Adam M Kaye, and Alan D Kaye.
• Department of Psychiatry, Harvard Medical School, Massachusetts General Hospital, 55 Fruit St, Boston, MA, 02114, USA. aedinoff@mgh.harvard.edu.
• Curr Pain Headache Rep. 2023 Sep 1; 27 (9): 387397387-397.

Purpose Of ReviewPostoperative pain (POP) is among the most unpleasant experiences that patients face after surgery. Interest in and use of N-methyl-D-aspartate (NMDA) receptor antagonists for the management of POP has increased over the years with ketamine being the most popular drug of this class.Recent FindingsSeveral randomized controlled trials found that the use of ketamine either alone or in combination with other medications leads to decreased postoperative pain and opioid consumption. However, there are other studies that have not found these benefits. The results as of now suggest that the role of intraoperative ketamine in postoperative pain control varies among different operative procedures. While some studies have shown promise in ketamine's potential use as a postoperative analgesic, there is still a great deal of proposed research and randomized controlled trials needed to deduce the most efficacious and tolerable form and dose of ketamine.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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