• Reintam BlaserAnnikaADepartment of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, 50406, Tartu, Estonia. annika.reintam.blaser@ut.ee.Department of Intensive Care Medicine, Lucerne Cantonal Hospital, Lucerne, Switzerland. annika.reinta, Olav Rooyackers, and Danielle E Bear.
• Department of Anaesthesiology and Intensive Care, University of Tartu, Puusepa 8, 50406, Tartu, Estonia. annika.reintam.blaser@ut.ee.
• Crit Care. 2023 Jul 1; 27 (1): 258258.

AbstractThe optimal feeding strategy in critically ill patients is a matter of debate, with current guidelines recommending different strategies regarding energy and protein targets. Several recent trials have added to the debate and question our previous understanding of the provision of nutrition during critical illness. This narrative review aims to provide a summary of interpretation of recent evidence from the view of basic scientist, critical care dietitian and intensivist, resulting in joined suggestions for both clinical practice and future research. In the most recent randomised controlled trial (RCT), patients receiving 6 versus 25 kcal/kg/day by any route achieved readiness for ICU discharge earlier and had fewer GI complications. A second showed that high protein dosage may be harmful in patients with baseline acute kidney injury and more severe illness. Lastly, a prospective observational study using propensity score matched analysis suggested that early full feeding, especially enteral, compared to delayed feeding is associated with a higher 28-day mortality. Viewpoints from all three professionals point to the agreement that early full feeding is likely harmful, whereas important questions regarding the mechanisms of harm as well as on timing and optimal dose of nutrition for individual patients remain unanswered and warrant future studies. For now, we suggest giving low dose of energy and protein during the first few days in the ICU and apply individualised approach based on assumed metabolic state according to the trajectory of illness thereafter. At the same time, we encourage research to develop better tools to monitor metabolism and the nutritional needs for the individual patient accurately and continuously.© 2023. The Author(s).

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