• Abimbola Adegbola, Karina Gritsenko, and Elilary Montilla Medrano.
• Montefiore Medical Center, 111 E 210Th Street, Bronx, NY, 10467, USA. aadegbola@montefiore.org.
• Curr Pain Headache Rep. 2023 Sep 1; 27 (9): 445448445-448.

Purpose Of ReviewPostoperative pain continues to be one of the most common challenges following surgeries. Multimodal analgesia has been of particular focus as non-opioid alternatives have been encouraged due to concerns of the opioid epidemic. Ketamine has been an especially useful adjunct in multimodal pain regimens within the past few decades. This article highlights the current use and advances surrounding the perioperative use of ketamine.Recent FindingsKetamine has antidepressive effects at subanesthetic doses. Intraoperative ketamine may be beneficial in reducing postoperative depression. Additionally, newer studies are exploring whether ketamine can be useful in reducing postoperative sleep disturbances. Ketamine continues to be a great tool in perioperative pain control, especially during an opioid epidemic. As its use continues to expand and gain more popularity in the perioperative period, more research could shed light on the additional nonanalgesic benefits of ketamine use.© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.

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