• Andreas Stallmach, Raja Atreya, Philip Christian Grunert, Johannes Stallhofer, Jan de Laffolie, and Carsten Schmidt.
• Department of Internal Medicine IV, Gastroenterology, Hepatology and Infectology, Jena University Hospital, Jena; Medical Department 1, University Hospital Erlangen-Nürnberg, Friedrich-Alexander-University Erlangen-Nürnberg; Center for Pediatric and Adolescent Medicine, Justus Liebig University, Gießen; Medical Department II, Gastroenterology, Hepatology, Endocrinology, Diabetology und Infectiology, Klinikum Fulda AG, Universitätsmedizin Marburg - Campus Fulda.
• Dtsch Arztebl Int. 2023 Nov 10; 120 (45): 768778768-778.

BackgroundThe prevalence of inflammatory bowel disease (IBD) is rising globally. In Germany, these conditions affect 0.7% of the population, or approximately 600 000 patients. Treatment strategies have become more diversified as a result of an improved understanding of disease pathogenesis. It remains unclear how the currently available drugs should best be used in each individual patient.MethodsThis review is based on pertinent publications retrieved by a selective search in PubMed, with special attention to phase III and IV trials and to the German and European guidelines on the treatment of IBD.ResultsAn improved understanding of the immunological mechanisms of disease underlies the current treatment strategies in patients with IBD. For those with a complex clinical course, monoclonal antibodies against pro-inflammatory cytokines (TNF, IL-12/IL-23, IL-23) and cell adhesion molecules (α4β7) are of established therapeutic value, along with "small molecules" such as JAK inhibitors and sphingosine-1-phosphate receptor modulators. The numerous studies that have been performed, only a few of which have been head-to-head comparison trials, and the (network) meta-analyses that have been published to date do not imply that any single one of these drugs can be considered the universal, primary treatment for all patients with IBD. In this review, we discuss the available substances and certain important differential-therapeutic aspects of the treatment of IBD.ConclusionThe treatment of a patient with IBD must take his or her prior treatment(s) and comorbidities into account, along with individual patient characteristics and treatment goals. Rational decision-making is required on the basis of the mechanism of action and the side-effect profile of the various drugs that are now available for use.

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