• Internal medicine · Mar 2024

    Case Reports

    Cardiac Tamponade as an Initial Manifestation of Diffuse Large B-cell Lymphoma One Year after IgG4-related Disease in Remission.

    • Soichiro Yamaji, Kenjiro Kamezaki, Maroka Shinchi, Katsumi Takizawa, Chie Abe, Akihiro Koike, and Mika Kuroiwa.
    • Department of Hematology, National Hospital Organization Fukuokahigashi Medical Center, Japan.
    • Intern. Med. 2024 Mar 1; 63 (5): 721727721-727.

    AbstractA 65-year-old man with multiple lymphadenopathies was diagnosed with IgG4-related disease (IgG4-RD) based on findings of a cervical lymph node biopsy and an elevated serum IgG4 level. Treatment was initiated after the onset of autoimmune pancreatitis, and he achieved remission. He developed diffuse large B-cell lymphoma one year later. Pericardial involvement of lymphoma resulted in cardiac tamponade, and he died before histopathological confirmation of lymphoma was made due to a lethal arrhythmia caused by massive involvement of lymphoma into the myocardium. Because patients with IgG4-RD might have an increased risk of malignant diseases, including lymphoma, histopathological examinations should be considered at any time during the course of IgG4-RD.

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