• Br J Anaesth · Sep 2023

    Editorial Comment

    What can ex vivo experiments contribute to clinical haemostasis management?

    • Keyvan Karkouti and Peter L Gross.
    • Department of Anesthesia and Pain Management, University Health Network, Sinai Health, and Women's College Hospital, University of Toronto, Toronto, ON, Canada. Electronic address: Keyvan.karkouti@uhn.ca.
    • Br J Anaesth. 2023 Sep 1; 131 (3): 424425424-425.

    AbstractA recent ex vivo study found that post-cardiopulmonary bypass platelet defects can be restored with supplemental fibrinogen, but the clinical significance of this finding will require further study. We propose that the best management strategy for achieving haemostasis in bleeding surgical patients is to identify individualised coagulation defects and then use a targeted therapeutic approach that addresses each identified defect systematically.Copyright © 2023 British Journal of Anaesthesia. Published by Elsevier Ltd. All rights reserved.

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