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- Joao F F M Ferraz, Matthew T Siuba, Sudhir Krishnan, Robert L Chatburn, Eduardo Mireles-Cabodevila, and Abhijit Duggal.
- Department of Hospital Medicine, Community Care Institute, Cleveland Clinic, 9500 Euclid Avenue, Cleveland, Ohio.
- Respir Care. 2023 Nov 25; 68 (12): 170817181708-1718.
AbstractDespite its significant limitations, the PaO2 /FIO2 remains the standard tool to classify disease severity in ARDS. Treatment decisions and research enrollment have depended on this parameter for over 50 years. In addition, several variables have been studied over the past few decades, incorporating other physiologic considerations such as ventilation efficiency, lung mechanics, and right-ventricular performance. This review describes the strengths and limitations of all relevant parameters, with the goal of helping us better understand disease severity and possible future treatment targets.Copyright © 2023 by Daedalus Enterprises.
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