• Clin J Pain · Nov 2023

    Risk Factors for the Development of Multisite Pain in Children.

    • Chelsea M Kaplan, Andrew Schrepf, Kevin F Boehnke, Ying He, Tristin Smith, David A Williams, Rachel Bergmans, Terri Voepel-Lewis, Afton L Hassett, Richard E Harris, Daniel J Clauw, Adriene M Beltz, and Steven E Harte.
    • Department of Anesthesiology, Michigan Medicine, Ann Arbor, MI.
    • Clin J Pain. 2023 Nov 1; 39 (11): 588594588-594.

    ObjectiveChronic pain has economic costs on par with cardiovascular disease, diabetes, and cancer. Despite this impact on the health care system and increasing awareness of the relationship between pain and mortality, efforts to identify simple symptom-based risk factors for the development of pain, particularly in children, have fallen short. This is critically important as pain that manifests during childhood often persists into adulthood. To date, no longitudinal studies have examined symptoms in pain-free children that presage a new, multisite manifestation of pain in the future. We hypothesized that female sex, sleep problems, and heightened somatic symptoms complaints at baseline would be associated with the risk of developing new multisite pain 1 year later.MethodsSymptom assessments were completed by parents of youth (ages 9 to 10) enrolled in the Adolescent Brain Cognitive Development study. Multivariate logistic regression models focused on children who developed multisite pain 1 year later (n=331) and children who remained pain free (n=3335).ResultsFemale sex (odds ratio [OR]=1.35; 95% CI, 1.07, 1.71; P =0.01), elevated nonpainful somatic symptoms (OR=1.17; 95% CI, 1.06, 1.29; P <0.01), total sleep problems (OR=1.20; 95% CI, 1.07, 1.34; P <0.01), and attentional issues (OR=1.22; 95% CI, 1.10, 1.35; P <0.001) at baseline were associated with new multisite pain 1 year later. Baseline negative affect was not associated with new multisite pain.DiscussionIdentifying symptom-based risk factors for multisite pain in children is critical for early prevention. Somatic awareness, sleep and attention problems represent actionable targets for early detection, treatment, and possible prevention of multisite pain in youth.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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