• Andreas Bender, Bernd Eifert, Ilona Rubi-Fessen, Ralf J Jox, Petra Maurer-Karattup, and Friedemann Müller.
• Therapiezentrum Burgau and Department of Neurology, LMU Klinikum, LMU München, Munich, Germany; SRH Hospital Neresheim, Neresheim, Germany; Rehanova Neurorehabilitation Center, Cologne, Germany and Faculty of Human Sciences, University of Cologne, Cologne, Germany; Institut des humanités en médecine, University Hospital and University of Lausanne, Switzerland; Schön Clinic Bad Aibling-Harthausen, Bad Aibling, Germany.
• Dtsch Arztebl Int. 2023 Sep 15; 120 (37): 605612605-612.

BackgroundSevere quantitative disorders of consciousness (DoC) due to acute brain injury affect up to 47% of patients upon admission to intensive care and early rehabilitation units. Nevertheless, the rehabilitation of this vulnerable group of patients has not yet been addressed in any German-language guidelines and has only been studied in a small number of randomized clinical trials.MethodsIn an S3 clinical practice guideline project, a systematic literature search was carried out for interventions that could improve consciousness in patients with coma, unresponsive wakefulness syndrome, or minimally conscious state after acute brain injury, and an evidence-based evaluation of these interventions was performed. Recommendations concerning diagnostic methods and medical ethics were issued by consensus.ResultsMisdiagnoses are common in patients with DoC, with minimal consciousness often going unrecognized. Patients with DoC should, therefore, be repeatedly assessed with standardized instruments, particularly the Coma Recovery Scale-Revised. The literature search yielded 54 clinical trials, mostly of low quality; there were two randomized controlled clinical trials providing level 1 evidence. The best available evidence for the improvement of impaired consciousness is for the administration of amantadine (4 studies) and for anodal transcranial direct-current stimulation of the left dorsolateral prefrontal cortex in patients in the minimal conscious state (8 studies, 2 systematic reviews). Further important components of rehabilitation include positioning methods and sensory stimulation techniques such as music therapy.ConclusionFor the first time, evidence-based German-language clinical practice guidelines have now become available for the neurological rehabilitation of patients with DoC.

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