• Peer Asad Aziz, Salma Farrukh Memon, Mubarak Hussain, A Rauf Memon, Kiran Abbas, Shurjeel Uddin Qazi, Riaz A R Memon, Kanwal Ali Qambrani, Osama Taj, Shamas Ghazanfar, Aayat Ellahi, and Moiz Ahmed.
• Department of Neurosurgery, Liaquat University of Medical Health Sciences, Jamshoro, Pakistan. Electronic address: azizpirasad@gmail.com.
• World Neurosurg. 2023 Nov 1; 179: e46e55e46-e55.

BackgroundThe severe neurologic tumor known as glioblastoma (GBM), also referred to as a grade IV astrocytoma, is rapidly progressive and debilitating. Supratotal resection (SpTR) is an emerging concept within glioma surgery, which aims to achieve a more extensive resection of the tumor than is possible with conventional techniques.MethodsWe performed a language-independent search of PubMed, Scopus, and Cochrane CENTRAL to identify all available literature up to August 2022 of patients undergoing SpTR assessing survival outcomes in comparison to other surgical modalities.ResultsAfter screening for exclusion, a total of 13 studies, all retrospective in design, were identified and included in our meta-analysis. SpTR was associated with significantly increased overall survival (hazard ratio 0.77, 95% CI 0.71-0.84; P < 0.01, I2 = 96%) and progression-free survival (hazard ratio 0.2, 95% CI 0.07-0.56; P = 0.002, I2 = 88%).ConclusionSpTR is associated with greater overall survival and PFS when compared with other glioblastoma surgeries like GTR or SubTR.Copyright © 2023. Published by Elsevier Inc.

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