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- Daisuke Suzuki, Daisuke Sato, Kenji Kikuchi, Takuma Suzuki, Kunie Sugasawa, Soichi Saito, Fumiaki Uchimura, and Yoshihiro Suzuki.
- Department of Neurology, Nihonkai General Hospital, Sakata, Yamagata, Japan. Electronic address: daisuke95230@yahoo.co.jp.
- Am. J. Med. Sci. 2023 Oct 1; 366 (4): 316320316-320.
AbstractBing-Neel syndrome, a rare neurological complication of Waldenström macroglobulinemia, is caused by the direct infiltration of malignant lymphoplasmacytic cells into the central nervous system. We report a patient who presented with back pain, weakness, lower extremity numbness, and gait disturbance accompanied by immunoglobulin M paraproteinemia and lymphoplasmacytic lymphoma in the bone marrow. Thoracic and lumbar magnetic resonance imaging revealed a long paravertebral mass around the spinal column, but the direct infiltration could not be proven. The patient was diagnosed with possible Bing-Neel syndrome and managed with bendamustine and rituximab. After chemotherapy, the patient's neurological and radiological findings improved. Magnetic resonance imaging should be considered when the Bing-Neel syndrome diagnosis is unclear.Copyright © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.
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