• Zane Elfessi, Danielle Dressler, Sara Johnson, Katerina Antonishina, and Melody Suh.
• Department of Emergency Medicine, Jesse Brown Veterans Affairs Medical Center, 820 S Damen Avenue, Chicago, IL 60612, United States of America; University of Illinois-Chicago College of Pharmacy, Department of Pharmacy Practice, 833 S Wood Street, Chicago, IL 60612, United States of America. Electronic address: zelfessi@uic.edu.
• Am J Emerg Med. 2023 Sep 1; 71: 249.e1249.e2249.e1-249.e2.

AbstractStrokes are the fifth leading cause of death in the United States with almost 800,000 patients seeking emergency care each year-most of whom are seen for ischemic strokes. Acute ischemic strokes (AIS) can be caused by emboli in diseases such as atrial fibrillation as well as thrombus formation in the form of platelet deposition in patients with atherosclerotic disease. Platelet activation by immunomodulators including thromboxane A2 (TXA2), serotonin, and thrombin have been extensively delineated; however, the activation by hormones such as prolactin has only recently been revealed. We present a case of a 25-year-old male with a history of pituitary microadenoma and hyperprolactinemia who presented with an acute ischemic stroke in the setting of medication non-compliance. To our knowledge, this is the first known case of AIS in a patient with known hyperprolactinemia who presented with a stroke due to be medication non-compliance.Published by Elsevier Inc.

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