• Journal of critical care · Dec 2023

    Multicenter Study Observational Study

    Association of plasma volume status with outcomes in hospitalized Covid-19 ARDS patients: A retrospective multicenter observational study.

    • Prasanth Balasubramanian, Shahin Isha, Abby J Hanson, Anna Jenkins, Parthkumar Satashia, Arvind Balavenkataraman, Iván A Huespe, Vikas Bansal, Sean M Caples, Syed Anjum Khan, Nitesh K Jain, Rahul Kashyap, Rodrigo Cartin-Ceba, Joseph L Nates, ReddyDereddi R SDRSDepartment of Critical Care Medicine, The University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America., Ricardo Diaz Milian, Houssam Farres, Archer K Martin, Parag C Patel, Michael A Smith, Anna B Shapiro, Anirban Bhattacharyya, Sanjay Chaudhary, Sean P Kiley, Quintin J Quinones, Neal M Patel, Pramod K Guru, Moreno FrancoPabloPDepartment of Critical Care Medicine, Mayo Clinic in Florida, Jacksonville, Florida, United States of America., and Devang K Sanghavi.
    • Department of Pulmonary and Critical Care, Mayo Clinic in Florida, Jacksonville, Florida, United States of America.
    • J Crit Care. 2023 Dec 1; 78: 154378154378.

    PurposeTo evaluate the association of estimated plasma volume (ePV) and plasma volume status (PVS) on admission with the outcomes in COVID-19-related acute respiratory distress syndrome (ARDS) patients.Materials And MethodsWe performed a retrospective multi-center study on COVID-19-related ARDS patients who were admitted to the Mayo Clinic Enterprise health system. Plasma volume was calculated using the formulae for ePV and PVS, and these variables were analyzed for correlation with patient outcomes.ResultsOur analysis included 1298 patients with sequential organ failure assessment (SOFA) respiratory score ≥ 2 (PaO2/FIO2 ≤300 mmHg) and a mortality rate of 25.96%. A Cox proportional multivariate analysis showed PVS but not ePV as an independent correlation with 90-day mortality after adjusting for the covariates (HR: 1.015, 95% CI: 1.005-1.025, p = 0.002 and HR 1.054, 95% CI 0.958-1.159, p = 0.278 respectively).ConclusionA lower PVS on admission correlated with a greater chance of survival in COVID-19-related ARDS patients. The role of PVS in guiding fluid management should be investigated in future prospective studies.Copyright © 2023 Elsevier Inc. All rights reserved.

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