• Georgios Mavrovounis, Marina Kontou, Orestis Tsiotsikas, Maria Mermiri, Vasiliki Tsolaki, Eleftherios Beltsios, Konstantinos Gourgoulianis, Athanasios Chalkias, and Ioannis Pantazopoulos.
• Department of Emergency Medicine, Faculty of Medicine, University of Thessaly, BIOPOLIS, 41500 Larissa, Greece. Electronic address: mavrovou@uth.gr.
• Am J Emerg Med. 2023 Oct 1; 72: 445744-57.

BackgroundThe Lazarus phenomenon or autoresuscitation (autoROSC) is the return of spontaneous circulation (ROSC) after the termination of the cardiopulmonary resuscitation (CPR) efforts.PurposeThe purpose of the current scoping review is to present the available data in the literature regarding autoROSC.MethodsWe reviewed four scientific databases to identify all studies which reported autoROSC cases in patients who underwent CPR. We then extracted all information relevant to CPR and autoROSC. The review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses Extension for Scoping Reviews.ResultsWe identified 66 studies describing 76 autoROSC cases. The majority of cardiac arrests were in-hospital (44, 57.89%). Median time from termination of CPR to autoROSC was 5 min. Regarding the outcome, 52 (77.61%) patients died and 11 (14.47%) patients had intact neurological outcome. A higher mortality rate was identified in patients with respiratory comorbidities. Overall, 24 (31.58%) patients survived.ConclusionAutoROSC is probably an under-reported event in the medical community. Healthcare professionals should be aware of the phenomenon and actively monitor for it, when appropriate.Copyright © 2023 Elsevier Inc. All rights reserved.

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