• Victor Lopez-Lopez, Michael Linecker, Albert Caballero-Llanes, Tim Reese, Karl J Oldhafer, Roberto Hernandez-Alejandro, Mauro Tun-Abraham, Jun Li, Mohammad Fard-Aghaie, Henrik Petrowsky, Roberto Brusadin, Asuncion Lopez-Conesa, Francesca Ratti, Luca Aldrighetti, Ali Ramouz, Arianeb Mehrabi, Autran MachadoMarcelMDepartment of Surgery, Hospital Adventista Silvestre, Rio de Janeiro, RJ, Brazil., Victoria Ardiles, Eduardo De Santibañes, Arthur Marichez, René Adam, Stéphanie Truant, Francois-René Pruvot, Pim B Olthof, Thomas M Van Gulick, Roberto Montalti, Roberto I Troisi, Philipp Kron, Peter Lodge, Patryk Kambakamba, Emir Hoti, Carlos Martinez-Caceres, Jesus de la Peña-Moral, Pierre-Alain Clavien, and Ricardo Robles-Campos.
• Department of Surgery and Liver and Pancreas transplantation, Virgen de la Arrixaca Clinic and University Hospital, IMIB, Murcia, Spain.
• Ann. Surg. 2024 Feb 1; 279 (2): 306313306-313.

Background And AimsAlterations in liver histology influence the liver's capacity to regenerate, but the relevance of each of the different changes in rapid liver growth induction is unknown. This study aimed to analyze the influence of the degree of histological alterations during the first and second stages on the ability of the liver to regenerate.MethodsThis cohort study included data obtained from the International ALPPS Registry between November 2011 and October 2020. Only patients with colorectal liver metastases were included in the study. We developed a histological risk score based on histological changes (stages 1 and 2) and a tumor pathology score based on the histological factors associated with poor tumor prognosis.ResultsIn total, 395 patients were included. The time to reach stage 2 was shorter in patients with a low histological risk stage 1 (13 vs 17 days, P ˂0.01), low histological risk stage 2 (13 vs 15 days, P <0.01), and low pathological tumor risk (13 vs 15 days, P <0.01). Regarding interval stage, there was a higher inverse correlation in high histological risk stage 1 group compared to low histological risk 1 group in relation with future liver remnant body weight ( r =-0.1 and r =-0.08, respectively), and future liver remnant ( r =-0.15 and r =-0.06, respectively).ConclusionsALPPS is associated with increased histological alterations in the liver parenchyma. It seems that the more histological alterations present and the higher the number of poor prognostic factors in the tumor histology, the longer the time to reach the second stage.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

20 keywords...

hide…