• Minerva medica · Feb 1979

    [Diagnosis of chronic reflux esophagitis. Role of endoscopic and histological examination].

    • M Bortolotti, S Mattioli, F Baldi, G Biasco, F Bassi, R B Bragaglia, A Cunsolo, G Di Febo, G Sansone, and G Sanavio.
    • Minerva Med. 1979 Feb 4; 70 (6): 465471465-71.

    AbstractFibroendoscopic and histobioptic study of the distal oesophageal mucosa has been carried out in a series of patients suffering from gastro-oesophageal regurgitation. The regurgitation condition was verified and its extent established by means of anamnestic, spot-fluorographic and manometric-pHmetric investigations. On the basis of the analysis of relations between the extent of the oesophagitis assessed on the basis of endoscopy and that arising out of microscopic examination of the biopsy, it is concluded that there is no complete correspondence between the two techniques insofar as endoscopy can give false positive or false negative results. On the basis of these results and of those of functional investigations, histology is considered desirable even when the oesophageal mucosa is normal, if there are clinical and/or laboratory signs of gastro-oesophageal regurgitation.

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