• Halil Çelik, Betül Emine Derinkuyu, Erhan Aksoy, Ülkühan Öztoprak, Nesrin Ceylan, Ebru Azapağası, Suna Özdem, Melek Melehat Oğuz, and Deniz Yüksel.
• Department of Pediatric Neurology, University of Health Sciences, Dr. Sami Ulus Maternity and Children's Health and Diseases Training and Research Hospital, Ankara, Turkey.
• Turk J Med Sci. 2022 Apr 1; 52 (2): 405412405-412.

BackgroundMild encephalitis/encephalopathy with a reversible splenial lesion (MERS) is a rare clinicoradiological syndrome that typically presents with central nervous system symptoms such as loss of consciousness, seizure, headache, and ophthalmoparesis.MethodsHere, we highlight the characteristics of this syndrome together with the clinical and MRI findings of 6 pediatric patients with MERS.ResultsBetween January 2017 and October 2020, 6 patients with MERS (3 boys and 3 girls) presented to our center. The mean age was 122 ± 54.6 (min-max: 44-180) months. None of the patients had a chronic disease. In our study, infectious agents were detected in 4 patients (66.6%), while noninfectious causes (one seizure and the other hyponatremia) were detected in two patients. All of our cases were discharged without any sequelae after an average of 12.1 ± 7 (min-max: 4-20) days of hospitalization. In 1 patient (case 6), control MRI could not be performed, and the radiological recovery of our other patients was shown to be between 14 days and 2 months.DiscussionMERS is an acute encephalopathy with good prognosis and should be considered by neurologists in differential diagnosis due to its variable clinical presentation and specific MRI findings.

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