• Gac Med Mex · Jan 2023

    NLRP3 inflammasome mechanism and therapeutic targets in diabetic cardiomyopathy.

    • Qing Sun, Wenxiu Guo, Tun Yue, Lu Wang, and Huaming Mou.
    • School of Clinical Medicine, North Sichuan Medical College, Nanchong, China.
    • Gac Med Mex. 2023 Jan 1; 159 (3): 255261255-261.

    AbstractDiabetic cardiomyopathy (DCM) is a serious complication of diabetes caused by oxidative stress, inflammation, insulin resistance, myocardial fibrosis, and lipotoxicity; its nature is insidious, complex and difficult to treat. NLRP3 inflammasome triggers the maturation and release of pro-inflammatory cytokines, participates in pathophysiological processes such as insulin resistance and myocardial fibrosis, in addition to being closely related to the development and progression of diabetic cardiomyopathy. The development of inhibitors targeting specific aspects of inflammation suggests that NLRP3 inflammasome can be used to treat diabetic cardiomyopathy. This paper aims to summarize NLRP3 inflammasome mechanism and therapeutic targets in diabetic cardiomyopathy, and to provide new suggestions for the treatment of this disease.Copyright: © 2023 Permanyer.

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