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- Yuji Kato, Shohei Iijima, Shinya Kohyama, Tomoya Maeda, Tsugumi Sato, Shinichi Takahashi, and Satoshi Suda.
- Department of Neurology and Cerebrovascular Medicine, Saitama Medical University International Medical Center, Japan.
- Intern. Med. 2024 Mar 15; 63 (6): 847852847-852.
AbstractEssential thrombocythemia is a myeloproliferative neoplasm. Ischemic stroke is frequently the first manifestation of essential thrombocythemia. We herein report a patient with JAK2V617 mutation-positive essential thrombocythemia who developed recurrent ischemic stroke with rapid development of intracranial artery stenosis and subsequently underwent successful mechanical thrombectomy. The high JAK2V617F allele burden in our patient (58.4%) may have affected the patient's condition. We discuss similar reports in the literature and the possible pathophysiologic mechanism of large artery involvement in these patients.
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