• Caroline Renner, Marie-Madlen Jeitziner, Monika Albert, Sabine Brinkmann, Karin Diserens, Imanuel Dzialowski, Maria-Dorothea Heidler, Martina Lück, Ricki Nusser-Müller-Busch, Peter S Sandor, Andreas Schäfer, Bettina Scheffler, Claus Wallesch, Gudrun Zimmermann, and Peter Nydahl.
• Department of Neurology and Neuro-Rehabilitation, Herz-Kreislauf-Zentrum, Klinikum Hersfeld-Rotenburg GmbH, Rotenburg a. F., University of Leipzig, Leipzig, Germany.
• Crit Care. 2023 Jul 31; 27 (1): 301301.

BackgroundIntensive Care Unit (ICU) survivors often experience several impairments in their physical, cognitive, and psychological health status, which are labeled as post-intensive care syndrome (PICS). The aim of this work is to develop a multidisciplinary and -professional guideline for the rehabilitative therapy of PICS.MethodsA multidisciplinary/-professional task force of 15 healthcare professionals applied a structured, evidence-based approach to address 10 scientific questions. For each PICO-question (Population, Intervention, Comparison, and Outcome), best available evidence was identified. Recommendations were rated as "strong recommendation", "recommendation" or "therapy option", based on Grading of Recommendations, Assessment, Development and Evaluation principles. In addition, evidence gaps were identified.ResultsThe evidence resulted in 12 recommendations, 4 therapy options, and one statement for the prevention or treatment of PICS.Recommendationsearly mobilization, motor training, and nutrition/dysphagia management should be performed. Delirium prophylaxis focuses on behavioral interventions. ICU diaries can prevent/treat psychological health issues like anxiety and post-traumatic stress disorders. Early rehabilitation approaches as well as long-term access to specialized rehabilitation centers are recommended. Therapy options include additional physical rehabilitation interventions. Statement: A prerequisite for the treatment of PICS are the regular and repeated assessments of the physical, cognitive and psychological health in patients at risk for or having PICS.ConclusionsPICS is a variable and complex syndrome that requires an individual multidisciplinary, and multiprofessional approach. Rehabilitation of PICS should include an assessment and therapy of motor-, cognitive-, and psychological health impairments.© 2023. The Author(s).

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