• J. Investig. Med. · Jan 2024

    Review

    EXPRESS: Novel Strategies for Chimeric Antigen Receptor T-Cell Therapy for Acute Lymphoblastic Leukemia: Moving Beyond CD19.

    • Luna Acharya, Alpana Garg, Manoj Rai, Rupesh Kshetri, Udhayvir S Grewal, and Prajwal Dhakal.
    • Division of Hematology, Oncology, and Blood and Marrow Transplantation, University of Iowa Hospitals and Clinics, Iowa City, IA, USA.
    • J. Investig. Med. 2024 Jan 1; 72 (1): 324632-46.

    AbstractAcute lymphoblastic leukemia (ALL) is the second most common acute leukemia in adults with a poor prognosis with relapsed or refractory (R/R) B-cell lineage ALL (B-ALL). Anti-CD19 chimeric antigen receptor (CAR) T-cell therapy has shown excellent response rates in RR B-ALL, but most patients relapse due to poor persistence of CAR T-cell therapy or other tumor-associated escape mechanisms. In addition, anti-CD19 CAR T-cell therapy causes several serious side effects such as cytokine release syndrome and neurotoxicity. In this review, we will discuss novel CAR targets, CAR constructs, and various strategies to boost CARs for the treatment of RR B-ALL. In addition, we discuss a few novel strategies developed to reduce the side effects of CAR.

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