• US Preventive Services Task Force, Michael J Barry, Wanda K Nicholson, Michael Silverstein, David Chelmow, Tumaini Rucker Coker, Esa M Davis, Katrina E Donahue, Carlos Roberto Jaén, Li Li, Gbenga Ogedegbe, Goutham Rao, John M Ruiz, James Stevermer, Joel Tsevat, Sandra Millon Underwood, and John B Wong.
• Harvard Medical School, Boston, Massachusetts.
• JAMA. 2023 Aug 1; 330 (5): 454459454-459.

ImportanceNeural tube defects are among the most common congenital malformations in the US, with an estimated 3000 pregnancies affected each year. Many of these neural tube defects are caused by low folate levels in the body.ObjectiveThe US Preventive Services Task Force (USPSTF) commissioned a reaffirmation evidence update on the benefits and harms of folic acid supplementation.PopulationPersons who are planning to or could become pregnant.Evidence AssessmentThe USPSTF concludes that, for persons who are planning to or could become pregnant, there is high certainty that folic acid supplementation has a substantial net benefit to prevent neural tube defects in their offspring.RecommendationThe USPSTF recommends that all persons planning to or who could become pregnant take a daily supplement containing 0.4 to 0.8 mg (400 to 800 μg) of folic acid. (A recommendation).

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