• Nadia N Hansel, Han Woo, Kirsten Koehler, Amanda Gassett, Laura M Paulin, Neil E Alexis, Nirupama Putcha, Wendy Lorizio, Ashraf Fawzy, Daniel Belz, Coralynn Sack, R Graham Barr, Fernando J Martinez, MeiLan K Han, Prescott Woodruff, Cheryl Pirozzi, Robert Paine, Igor Barjaktarevic, Christopher B Cooper, Victor Ortega, Marina Zusman, and Joel D Kaufman.
• Division of Pulmonary and Critical Care Medicine and.
• Am. J. Respir. Crit. Care Med. 2023 Nov 15; 208 (10): 104210511042-1051.

AbstractRationale: Indoor pollutants have been associated with chronic obstructive pulmonary disease morbidity, but it is unclear whether they contribute to disease progression. Objectives: We aimed to determine whether indoor particulate matter (PM) and nitrogen dioxide (NO2) are associated with lung function decline among current and former smokers. Methods: Of the 2,382 subjects with a history of smoking in SPIROMICS AIR, 1,208 participants had complete information to estimate indoor PM and NO2, using individual-based prediction models, in relation to measured spirometry at two or more clinic visits. We used a three-way interaction model between time, pollutant, and smoking status and assessed the indoor pollutant-associated difference in FEV1 decline separately using a generalized linear mixed model. Measurements and Main Results: Participants had an average rate of FEV1 decline of 60.3 ml/yr for those currently smoking compared with 35.2 ml/yr for those who quit. The association of indoor PM with FEV1 decline differed by smoking status. Among former smokers, every 10 μg/m3 increase in estimated indoor PM was associated with an additional 10 ml/yr decline in FEV1 (P = 0.044). Among current smokers, FEV1 decline did not differ by indoor PM. The results of indoor NO2 suggest trends similar to those for PM ⩽2.5 μm in aerodynamic diameter. Conclusions: Former smokers with chronic obstructive pulmonary disease who live in homes with high estimated PM have accelerated lung function loss, and those in homes with low PM have lung function loss similar to normal aging. In-home PM exposure may contribute to variability in lung function decline in people who quit smoking and may be a modifiable exposure.

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