• Amir Qaseem, Curtis S Harrod, Carolyn J Crandall, Timothy J Wilt, Clinical Guidelines Committee of the American College of Physicians, Ethan M Balk, Thomas G Cooney, J Thomas Cross, Nick Fitterman, Michael Maroto, Adam J Obley, Jeffrey Tice, Janice E Tufte, Tatyana Shamliyan, and Jennifer Yost.
• American College of Physicians, Philadelphia, Pennsylvania (A.Q., C.S.H.).
• Ann. Intern. Med. 2023 Aug 1; 176 (8): 109211001092-1100.

DescriptionThe purpose of this updated guidance statement is to guide clinicians on screening for colorectal cancer (CRC) in asymptomatic average-risk adults. The intended audience is all clinicians. The population is asymptomatic adults at average risk for CRC.MethodsThis updated guidance statement was developed using recently published and critically appraised clinical guidelines from national guideline developers since the publication of the American College of Physicians' 2019 guidance statement, "Screening for Colorectal Cancer in Asymptomatic Average-Risk Adults." The authors searched for national guidelines from the United States and other countries published in English using PubMed and the Guidelines International Network library from 1 January 2018 to 24 April 2023. The authors also searched for updates of guidelines included in the first version of our guidance statement. The Appraisal of Guidelines for Research and Evaluation II (AGREE II) instrument was used to assess the quality of eligible guidelines. Two guidelines were selected for adoption and adaptation by raters on the basis of the highest average overall AGREE II quality scores. The evidence reviews and modeling studies for these 2 guidelines were also used to synthesize the evidence of diagnostic test accuracy, effectiveness, and harms of CRC screening interventions and to develop our guidance statements.Guidance Statement 1Clinicians should start screening for colorectal cancer in asymptomatic average-risk adults at age 50 years.Guidance Statement 2Clinicians should consider not screening asymptomatic average-risk adults between the ages of 45 to 49 years. Clinicians should discuss the uncertainty around benefits and harms of screening in this population.Guidance Statement 3Clinicians should stop screening for colorectal cancer in asymptomatic average-risk adults older than 75 years or in asymptomatic average-risk adults with a life expectancy of 10 years or less.Guidance Statement 4 AClinicians should select a screening test for colorectal cancer in consultation with their patient based on a discussion of benefits, harms, costs, availability, frequency, and patient values and preferences.Guidance Statement 4 BClinicians should select among a fecal immunochemical or high-sensitivity guaiac fecal occult blood test every 2 years, colonoscopy every 10 years, or flexible sigmoidoscopy every 10 years plus a fecal immunochemical test every 2 years as a screening test for colorectal cancer.Guidance Statement 4 CClinicians should not use stool DNA, computed tomography colonography, capsule endoscopy, urine, or serum screening tests for colorectal cancer.

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