• Internal medicine · Mar 2024

    Silent Thyroiditis Associated with Ropeginterferon Alfa-2b in a Patient with Polycythemia Vera.

    • Keita Kirito.
    • Department of Hematology and Oncology, University of Yamanashi, Japan.
    • Intern. Med. 2024 Mar 15; 63 (6): 843846843-846.

    AbstractInterferon is an emerging treatment option for myeloproliferative neoplasms (MPNs), especially for polycythemia vera (PV). Previous studies of interferon used therapeutically for hepatitis C have demonstrated that one of the most important adverse events associated with interferon treatment is thyroid dysfunction, and a management strategy for thyroid dysfunction has been established. However, whether or not the recommendation is also suitable for MPN settings is unclear. In this study, one PV patient developed silent thyroiditis during a phase 2 study of ropeginterferon α-2b. This case suggests that thyroid dysfunction is an important clinical issue to consider in interferon treatment for PV.

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