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Review Case Reports
Immune Checkpoint Inhibitor-induced Pancreatitis with Pancreatic Enlargement Mimicking Autoimmune Pancreatitis: A Case Report and Review of the Literature.
- Kiyokuni Tanabe, Kensuke Yokoyama, Atsushi Kanno, Eriko Ikeda, Kozue Ando, Hiroki Nagai, Takahiro Koyanagi, Mio Sakaguchi, Takeo Nakaya, Kiichi Tamada, Toshiro Niki, Noriyoshi Fukushima, Alan Kawarai Lefor, and Hironori Yamamoto.
- Department of Medicine, Division of Gastroenterology, Jichi Medical University, Japan.
- Intern. Med. 2024 Mar 15; 63 (6): 791798791-798.
AbstractA 61-year-old woman was administered 35 cycles of pembrolizumab for the treatment of recurrent endometrial cancer, achieving a complete response. She presented with asymptomatic pancreatic enlargement and elevated hepatobiliary enzymes, but amylase and lipase levels were within the normal ranges. Intrapancreatic bile duct stenosis due to pancreatic enlargement was present, mimicking autoimmune pancreatitis on computed tomography performed before the onset of clinical manifestations. A histological examination of a biopsy specimen showed lymphocyte and plasma cell infiltration with dense fibrosis in the stroma. The patient was successfully treated with oral prednisolone. There were no manifestations of recurrent pancreatitis after tapering the prednisolone dose.
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