• Internal medicine · Apr 2024

    PD-L1-negative Non-small-cell Lung Cancer Treated with Nivolumab Plus Ipilimumab During Maintenance Hemodialysis Results in Rapid Initial Progression Followed by a Long-lasting Response.

    • Shohei Yano, Shinya Uematsu, Naohiro Kunimune, Tomoko Harima, Yuki Yoshida, Shota Takahashi, Masahiro Ito, Hiroto Sakamoto, and Yasuo Nishizaka.
    • Department of Respiratory Medicine, Osaka Red Cross Hospital, Japan.
    • Intern. Med. 2024 Apr 1; 63 (7): 985988985-988.

    AbstractNivolumab plus ipilimumab is one of the first-line treatments for advanced non-small-cell lung cancer (NSCLC), but the safety and efficacy in patients on hemodialysis (HD) is unclear. We herein report a patient with NSCLC on HD in whom nivolumab and ipilimumab were initiated. We observed general deterioration and enlarged lesions, followed by a long-term response. The patient developed secondary hypoadrenocorticism, an immune-related adverse event that was easily controlled. Nivolumab plus ipilimumab can be used safely for patients with NSCLC on HD. Long-term effectiveness can be observed after initial progression, so we should carefully assess the response.

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