• Ting Zhan, Shanshan Xing, and Chunhua Lu.
• Department of Radiology, the Second Affiliated Hospital of Nanchang University, Nanchang, China.
• Medicine (Baltimore). 2023 Aug 4; 102 (31): e34289e34289.

RationaleFollicular dendritic cell sarcoma (FDCS) is a rare mesenchymal tumor that typically develops in lymph nodes; it is clinically uncommon and has only occasionally been documented in cases of soft tissue, liver and spleen, and retroperitoneum; it is also extremely uncommon to develop in the stomach.Patient ConcernsA 64-year-old woman who discovered a lump in her left upper abdomen 6 months prior and was taken to the hospital due to excruciating abdominal pain.DiagnosisAn abdominal computed tomography scan showed a soft tissue mass around the cardia. The immunohistochemical and postoperative histopathology results were compatible with FDCS.InterventionsThe patient underwent "radical total gastrectomy and esophagojejunostomy" (Roux-Y anastomosis).OutcomesThe patient recovered well 2 months after surgery.LessonsWe report a case of FDCS occurring in the stomach and abdominal cavity, which was unique in terms of clinical location, clinical presentation, and imaging signs. This case report aims to enhance clinicians' understanding and diagnosis of FDCS in the stomach and abdominal cavity and reduce the rate of clinical misdiagnosis.Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc.

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