• Kenichi Matsushita, Junnosuke Ito, Aoi Isaka, Satoshi Higuchi, Toshinori Minamishima, Konomi Sakata, Toru Satoh, and Kyoko Soejima.
• Department of Cardiovascular Medicine, Kyorin University School of Medicine, Tokyo 181-8611, Japan; Division of Advanced Cardiovascular Therapeutics, Department of Cardiovascular Medicine, Kumamoto University Hospital, Kumamoto 860-8556, Japan; Department of Cardiology, Saitama Medical University International Medical Center, Saitama 350-1298, Japan; The Maruki Memorial Medical and Social Welfare Center, Saitama 350-0495, Japan; National Research Institute for Child Health and Development, Tokyo 157-8535, Japan. Electronic address: kenichi-matsushita@umin.ac.jp.
• Am. J. Med. Sci. 2023 Nov 1; 366 (5): 360366360-366.

BackgroundPathophysiologically, an elevated left ventricular (LV) filling pressure is the major reason for heart failure (HF) readmission. The 2016 American Society of Echocardiography (ASE)/European Association of Cardiovascular Imaging (EACVI) guidelines provide a simplified algorithm for the echocardiographic assessment of LV filling pressure; however, this algorithm is yet to be sufficiently validated.Materials And MethodsWe retrospectively studied 139 consecutive patients with acute decompensated HF. High estimated left atrial pressure (eLAP) was defined according to the 2016 ASE/EACVI guidelines. Univariate and multivariate logistic regression analyses were performed to identify significant risk factors for HF readmission within one year of discharge.ResultsAcross the study cohort, 68 patients (49%) did not have a high eLAP, 32 (23%) had an indeterminate eLAP, and 39 (28%) had a high eLAP. The number of HF readmission events within one year in the without high eLAP, indeterminate, and high eLAP groups were 4 (7.5%), 5 (18.5%), and 10 (33.3%), respectively. The HF readmission rate was significantly higher in patients with high eLAP than in those without high eLAP. Multivariate analysis revealed high eLAP (odds ratio, 5.924; 95% confidence interval, 1.664-21.087; P = 0.006) as a significant risk factor for HF readmission within one year. Furthermore, the exploratory analysis of the two-year outcomes revealed a similar finding: patients with high eLAP had a significantly higher rate of readmission for HF.ConclusionsThe present study demonstrated that echocardiographic assessment of elevated LAP based on the 2016 ASE/EACVI guidelines is clinically valid for predicting readmission in patients with HF.Copyright © 2023 Southern Society for Clinical Investigation. Published by Elsevier Inc. All rights reserved.

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