• Ehab Farag, Sandra Machado, and Maged Argalious.
• Department of General Anesthesiology, Anesthesia Institute, Cleveland Clinic, Ohio, USA.
• Curr Opin Anaesthesiol. 2023 Oct 1; 36 (5): 476484476-484.

Purpose Of ReviewThe brain is the command center of the rest of the body organs. The normal multiorgan talks between the brain and the rest of the body organs are essential for the normal body homeostasis. In the presence of brain injury, the disturbed talks between the brain and the rest of body organs will result in several pathological conditions. The aim of this review is to present the most recent findings for the pathological conditions that would result from the impaired multiorgan talks in the presence of brain injury.Recent FindingsThe brain injury such as in acute ischemic stroke, subarachnoid hemorrhage and traumatic brain injury will result in cascade of pathological talks between the brain and the rest of body organs. These pathological talks could result in pathological conditions such as cardiomyopathy, acute lung and kidney injuries, impaired liver functions, and impaired gut barrier permeability as well.SummaryBetter understanding of the pathological conditions that could result from the impaired multiorgan talks in the presence of brain injury will open the doors for precise targeted therapies in the future for myriad of pathological conditions.Copyright © 2023 Wolters Kluwer Health, Inc. All rights reserved.

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