• Annals of medicine · Jan 2023

    Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis.

    • Xiao-Yan Li, Xi Wang, Zhi-Yue Gu, Ting-Ting Sun, Jin-Hua Leng, and Qi Yu.
    • Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, PR China.
    • Ann. Med. 2023 Jan 1; 55 (2): 22438252243825.

    ObjectiveTo explore potential biomarkers indicating endometriosis (EM).Materials And MethodsA proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM. Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles. Promising candidate markers were tested by enzyme-related immunosorbent assay.ResultsA sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the EM cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e. fetuin B (FETUB) and serpin family C member 1 (SERPINC1); the latter showed a big variance between the control category and the EM set in the authentication test.ConclusionSERPINC1 may be a useful possible biomarker for the analysis of EM.

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