• Sheer Shabat, Ronit Grinbaum, Yoram Kluger, Haggi Mazeh, Zvi Ackerman, Orit Pappo, and Offir Ben-Ishay.
• Department of Rehabilitation, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Israel.
• Isr Med Assoc J. 2023 Aug 1; 25 (8): 538541538-541.

BackgroundSignet ring cell carcinoma (SRCC) is classified as an undifferentiated gastric carcinoma with poor prognosis. Early SRCCs are associated with improved prognosis.ObjectivesTo describe the outcomes of incidental SRCC.MethodsIn this case series, 900 medical charts of patients with SRCC were screened to identify patients with incidental SRCC, defined as diagnosed in random, non-focal-lesion-targeted biopsies.ResultsSix patients were diagnosed with incidental SRCC and underwent gastrectomy. The final pathology of five patients revealed one or more small foci of early SRCC without lymphovascular invasion. Only one patient had no evidence of malignancy. The median follow-up after surgery was 4.2 years (50 months, range 37-90 months). No deaths or recurrences were recorded during the follow-up period. These results resemble the reported survival rate for early SRCC.ConclusionsAn aggressive surgical approach in incidental gastric SRCC patients is recommended, as they have a chance for long-term survival.

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