• Internal medicine · Mar 2024

    Case Reports

    Paraneoplastic Cerebellar Degeneration Accompanied by Seropositivity for Anti-GAD65, Anti-SOX-1 and Anti-VGCC Antibodies Due to Small-cell Lung Cancer.

    • Naomi Takahashi, Ryosuke Igari, Chifumi Iseki, Hikaru Kawahara, Daisuke Suzuki, Yuya Suzuki, Hiroyasu Sato, Shingo Koyama, Maki Kobayashi, and Yasuyuki Ohta.
    • Division of Neurology and Clinical Neuroscience, Department of Internal Medicine III, Yamagata University School of Medicine, Japan.
    • Intern. Med. 2024 Mar 15; 63 (6): 857860857-860.

    AbstractParaneoplastic cerebellar degeneration (PCD) is a paraneoplastic neurological syndrome that is rarely accompanied by seropositivity with a combination of multiple antibodies. We herein report a 50-year-old man with PCD accompanied by small-cell lung cancer (SCLC). This patient was seropositive for anti-glutamic acid decarboxylase 65, anti-SRY-related HMG-box gene 1 and anti-voltage-gated calcium channel antibodies. After chemoradiation therapy without immunotherapy, cerebellar ataxia of the trunk and limbs markedly improved, along with a notable amelioration of SCLC. This case suggests that tumor therapy should be started immediately and that a panel of anti-neuronal antibodies should be evaluated when PCD with SCLC is suspected.

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