• Internal medicine · Jan 2023

    Case Reports

    Acute Interstitial Nephritis with Glomerular Capillary IgA Deposition Following SARS-CoV-2 mRNA Vaccination.

    • Erika Hishida, Yuko Ono, Kazuho Oe, Toshimi Imai, Hiromichi Yoshizawa, Takeo Nakaya, Hirotoshi Kawata, Tetsu Akimoto, Osamu Saito, and Daisuke Nagata.
    • Division of Nephrology, Department of Internal Medicine, Jichi Medical University, Japan.
    • Intern. Med. 2023 Jan 1; 62 (16): 238123872381-2387.

    AbstractWe herein report a case of acute kidney injury (AKI) presenting as acute interstitial nephritis (AIN) after the first dose of the BNT162b2 mRNA vaccine against coronavirus disease 2019 (COVID-19). A 69-year-old man with a history of diabetes and hypertension presented with AKI 4 days after receiving the vaccine. Despite the administration of methylprednisolone pulse treatment, his renal function worsened, which prompted us to initiate temporal hemodialysis. His renal function subsequently improved, and a renal biopsy confirmed AIN and glomerular capillary IgA deposition without apparent crescents. The clinical history and histological findings suggest a relationship between severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination and AIN as a rare side effect.

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